Background: Use of ultrasound in brain tumor surgery is common. The difference in attenuation between brain\nand isotonic saline may cause artifacts that degrade the ultrasound images, potentially affecting resection grades\nand safety. Our research group has developed an acoustic coupling fluid that attenuates ultrasound energy like the\nnormal brain. We aimed to test in animals if the newly developed acoustic coupling fluid may have harmful effects.\nMethods: Eight rats were included for intraparenchymal injection into the brain, and if no adverse reactions were\ndetected, 6 pigs were to be included with injection of the coupling fluid into the subarachnoid space. Animal\nbehavior, EEG registrations, histopathology and immunohistochemistry were used in assessment.\nResults: In total, 14 animals were included, 8 rats and 6 pigs. We did not detect any clinical adverse effects, seizure\nactivity on EEG or histopathological signs of tissue damage.\nConclusion: The novel acoustic coupling fluid intended for brain tumor surgery appears safe in rats and pigs under\nthe tested circumstances.
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